PHARMACOKINETIC PROFILE OF RECOMBINANT HUMAN INSULIN-LIKE GROWTH FACTOR-I GIVEN SUBCUTANEOUSLY IN NORMAL SUBJECTS

被引:0
作者
WILTON, P
SIETNIEKS, A
GUNNARSSON, R
BERGER, L
GRAHNEN, A
机构
[1] PROFESS MED CONSULTANTS,UPPSALA,SWEDEN
[2] KABI PHARM PEPTIDE HORMONES,DEPT RES & DEV,S-11287 STOCKHOLM,SWEDEN
来源
ACTA PAEDIATRICA SCANDINAVICA | 1991年
关键词
INSULIN-LIKE GROWTH FACTOR-I; PHARMACOKINETICS; HYPOGLYCEMIA; INSULIN;
D O I
暂无
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The pharmacokinetic profile of recombinant human insulin-like growth factor I (IGF-1) was studied in healthy volunteers. Following a single subcutaneous injection of 40-mu-g/kg or 80-mu-g/kg, mean serum IGF-I concentrations increased by 150 ng/ml and 245 ng/ml, respectively. During repeated daily injections of 40-mu-g/kg, a steady-state IGF-I leveL of 150 ng/ml above baseline was reached. Of the pharmacokinetic indices measured, only T(max) varied between single and multiple dose regimens (6.9 hours versus 3.5 hours). No hypoglycaemic symptoms were observed, and after injection of IGF-I no depression of endogenous IGF-I production was observed. Fasting insulin levels were unaltered, but postprandial insulin was lowered by IGF-I with respect to placebo.
引用
收藏
页码:111 / 114
页数:4
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