EFFECT OF FOOD ON THE BIOAVAILABILITY OF BROMAZEPAM FOLLOWING ORAL-ADMINISTRATION IN HEALTHY-VOLUNTEERS

The effect of food on the rate and extent of bioavailability of bromazepam was examined in seven normal volunteers following a single oral dose of 10 mg bromazepam with 200 ml of water in the fasting and non-fasting states. Plasma concentrations of bromazepam were measured by high pressure liquid chromatography. A tmax value in a non-fasting state was prolonged from 2.3±0.3 (mean±S.E.M.) to 2.8±0.6 h but not significantly different (p > 0.05) whereas a Cmax value was significantly (p < 0.05) decreased from 259±12.7 (mean±S.E.M.) to 169±13.9 ng/ml. The area under the plasma concentration-time curve in the non-fasting state was also significantly (p < 0.05) decreased from 1844±145 (mean±S.E.M.) to 1233±98.1 ng∙h/ml after oral administration of bromazepam. © 1990, The Pharmaceutical Society of Japan. All rights reserved.