Cerebral tuberculoma as a manifestation of paradoxical reaction in patients with pulmonary and extrapulmonary tuberculosis

被引:12
作者
Das, Anirban [1 ]
Das, Sibes Kumar [1 ]
Mandal, Abhijit [2 ]
Halder, Arup Kumar [3 ]
机构
[1] Med Coll, Dept Resp Med, Kolkata, India
[2] BS Med Coll, Bankura, India
[3] Columbia Asia Hosp, Dept Resp Med, Kolkata, W Bengal, India
关键词
Intracranial; paradoxical reaction; tuberculoma; tuberculosis;
D O I
10.4103/0976-3147.102622
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Expansion of cerebral tuberculomas or their new appearance as a manifestation of paradoxical reaction in patients under antituberculous chemotherapy is well documented. Distinguishing paradoxical reaction from disease progression or treatment failure is an important issue in tuberculosis management. Five cases of cerebral tuberculomas are reported here as manifestations of paradoxical reaction in patients with pulmonary and extrapulmonary tuberculosis on antituberculous treatment. Case 1 and 2 had tuberculous meningitis, Case 3 had miliary tuberculosis, Case 4 had miliary tuberculosis and destructive vertebral lesions, and Case 5 had pulmonary tuberculosis. Continuation of antituberculous drugs and addition of steroids led to full recovery of all patients.
引用
收藏
页码:350 / 354
页数:5
相关论文
共 17 条
[1]   PARADOXICAL ENLARGEMENT OR DEVELOPMENT OF INTRACRANIAL TUBERCULOMAS DURING THERAPY - CASE-REPORT AND REVIEW [J].
AFGHANI, B ;
LIEBERMAN, JM .
CLINICAL INFECTIOUS DISEASES, 1994, 19 (06) :1092-1099
[2]   Therapeutic Use of Infliximab in Tuberculosis to Control Severe Paradoxical Reaction of the Brain and Lymph Nodes [J].
Blackmore, Timothy K. ;
Manning, Laurens ;
Taylor, William J. ;
Wallis, Robert S. .
CLINICAL INFECTIOUS DISEASES, 2008, 47 (10) :E83-E85
[3]   Paradoxical reactions during tuberculosis treatment in patients with and without HIV co-infection [J].
Breen, RAM ;
Smith, CJ ;
Bettinson, H ;
Dart, S ;
Bannister, B ;
Johnson, MA ;
Lipman, MCI .
THORAX, 2004, 59 (08) :704-707
[4]   Treatment of HIV-related tuberculosis in the era of effective antiretroviral therapy [J].
Burman, WJ ;
Jones, BE .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 164 (01) :7-12
[5]   Risk factors for development of paradoxical response during antituberculosis therapy in HIV-negative patients [J].
Cheng, VCC ;
Yam, WC ;
Woo, PCY ;
Lau, SKP ;
Hung, IFN ;
Wong, SPY ;
Cheung, WC ;
Yuen, KY .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2003, 22 (10) :597-602
[6]  
Church P, 2007, TUBERCULOSIS NONTUBE, P400
[7]   Splenic abscess as a paradoxical response to chemotherapy in tuberculous pleural effusion [J].
Dixit, Ramakant ;
Nuwal, Paras ;
Arya, Manoj .
ANNALS OF THORACIC MEDICINE, 2010, 5 (01) :50-51
[8]  
Jniene A, 2010, TUBERK TORAK, V58, P366
[9]   Atypical response to chemotherapy in neurotuberculosis [J].
Kumar, R .
BRITISH JOURNAL OF NEUROSURGERY, 1998, 12 (04) :344-348
[10]   Immune reconstitution disease associated with mycobacterial infections in HIV-infected individuals receiving antiretrovirals [J].
Lawn, SD ;
Bekker, LG ;
Miller, RF .
LANCET INFECTIOUS DISEASES, 2005, 5 (06) :361-373