Autologous Stem Cell Therapy: How Aging and Chronic Diseases Affect Stem and Progenitor Cells

被引：60
作者：
Efimenko, Anastasia Yu. [1 ]
Kochegura, Tatiana N. [1 ]
Akopyan, Zhanna A. [1 ]
Parfyonova, Yelena V. [1 ,2 ]
机构：
[1] Moscow MV Lomonosov State Univ, Fac Med, Dept Biochem & Mol Med, Moscow 119192, Russia
[2] Russian Cardiol Res & Prod Complex, Lab Angiogenesis, Moscow, Russia
来源：
BIORESEARCH OPEN ACCESS | 2015年 / 4卷 / 01期
关键词：
D O I：
10.1089/biores.2014.0042
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
During recent years different types of adult stem/progenitor cells have been successfully applied for the treatment of many pathologies, including cardiovascular diseases. The regenerative potential of these cells is considered to be due to their high proliferation and differentiation capacities, paracrine activity, and immunologic privilege. However, therapeutic efficacy of the autologous stem/progenitor cells for most clinical applications remains modest, possibly because of the attenuation of their regenerative potential in aged patients with chronic diseases such as cardiovascular diseases and metabolic disorders. In this review we will discuss the risk factors affecting the therapeutic potential of adult stem/progenitor cells as well as the main approaches to mitigating them using the methods of regenerative medicine.
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收藏
页码：26 / 38
页数：13
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