A NEW DETECTOR FOR FULLY-AUTOMATIC PEPTIDE-SYNTHESIS

被引：0

作者：

FOX, JE ^{[1
]}

NEWTON, R ^{[1
]}

STROUD, CH ^{[1
]}

机构：

[1] BIOTECH INSTRUMENTS LTD,LUTON,ENGLAND

来源：

INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH | 1991年 / 38卷 / 01期

关键词：

AUTOMATIC; CONDUCTIVITY; PEPTIDE; SYNTHESIS;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new method of monitoring the rate of reactions in solid phase peptide synthesis is described. A conductivity detector in the reaction cell enables the deprotection, washing, and subsequent coupling stages to be examined in detail. The half lives of the reactions can be calculated and hence the optimum reaction times predicted. The aggregation of peptide chains and subsequent collapse of the resin is observed. Difficult sequences are sensed and appropriate action taken completely automatically.

引用

页码：62 / 65

页数：4

共 10 条

[1]

AHMON M, 1978, ELECTRONICS, P132

[2] SELF-INDICATING ACTIVATED ESTERS FOR USE IN SOLID-PHASE PEPTIDE-SYNTHESIS - FLUORENYLMETHOXYCARBONYLAMINO ACID-DERIVATIVES OF 3-HYDROXY-4-OXODIHYDROBENZOTRIAZINE [J].