BETA-CARBOLINE ALKALOIDS .7. 1,9-DIMETALLATED BETA-CARBOLINES - VERSATILE BUILDING-BLOCKS FOR THE TOTAL SYNTHESIS OF ALKALOIDS

被引：43
|
作者：
BRACHER, F [1 ]
HILDEBRAND, D [1 ]
机构：
[1] INST PHARMAZEUT CHEM,D-35037 MARBURG,GERMANY
来源：
TETRAHEDRON | 1994年 / 50卷 / 43期
关键词：
D O I：
10.1016/S0040-4020(01)89542-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reactions of the dimetalated beta-carboline 6, prepared from 1-bromo-beta-carboline (4), with electrophiles are key steps in the syntheses of various beta-carboline alkaloids. Transmetalation of 6 with ZnCl2 followed by palladium-catalyzed cross coupling reaction with 2-chloxoquinoline gave the alkaloid nitramarine (14).
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页码：12329 / 12336
页数：8
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