MODE OF ACTION OF BULLATACIN - A POTENT ANTITUMOR AND PESTICIDAL ANNONACEOUS ACETOGENIN

被引：186

作者：

AHAMMADSAHIB, KI

HOLLINGWORTH, RM

MCGOVREN, JP

HUI, YH

MCLAUGHLIN, JL

机构：

[1] UPJOHN CO, CANC & INFECT DIS RES, KALAMAZOO, MI 49001 USA

[2] PURDUE UNIV, SCH PHARM & PHARMACAL SCI, DEPT MED CHEM & PHARMACOGNOSY, W LAFAYETTE, IN 47907 USA

来源：

LIFE SCIENCES | 1993年 / 53卷 / 14期

关键词：

D O I：

10.1016/0024-3205(93)90547-G

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Bullatacin, a compound isolated from plants of the Annonaceae, and its analogues show in vivo potential as antitumor agents based on their efficacy in normal mice bearing L1210 murine leukemia and athymic mice bearing A2780 conventional ovarian cancer xenografts. These compounds also have interesting potential as insecticides and inhibit respiration in insect-derived Sf9 cells with high potency. Their toxicity in both cases probably arises from their strong inhibition of mitochondrial electron transport with a specific action at complex I.

引用

页码：1113 / 1120

页数：8

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