MODE OF ACTION OF BULLATACIN - A POTENT ANTITUMOR AND PESTICIDAL ANNONACEOUS ACETOGENIN

被引：185
作者：
AHAMMADSAHIB, KI
HOLLINGWORTH, RM
MCGOVREN, JP
HUI, YH
MCLAUGHLIN, JL
机构：
[1] UPJOHN CO, CANC & INFECT DIS RES, KALAMAZOO, MI 49001 USA
[2] PURDUE UNIV, SCH PHARM & PHARMACAL SCI, DEPT MED CHEM & PHARMACOGNOSY, W LAFAYETTE, IN 47907 USA
来源：
LIFE SCIENCES | 1993年 / 53卷 / 14期
关键词：
D O I：
10.1016/0024-3205(93)90547-G
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Bullatacin, a compound isolated from plants of the Annonaceae, and its analogues show in vivo potential as antitumor agents based on their efficacy in normal mice bearing L1210 murine leukemia and athymic mice bearing A2780 conventional ovarian cancer xenografts. These compounds also have interesting potential as insecticides and inhibit respiration in insect-derived Sf9 cells with high potency. Their toxicity in both cases probably arises from their strong inhibition of mitochondrial electron transport with a specific action at complex I.
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页码：1113 / 1120
页数：8
相关论文
共 20 条
  • [1] BISSERY MC, 1991, CANCER RES, V51, P4845
  • [2] EFFECTS OF PROTEOLYTIC DIGESTION BY CHYMOTRYPSIN ON STRUCTURE AND CATALYTIC PROPERTIES OF REDUCED NICOTINAMIDE-ADENINE DINUCLEOTIDE-UBIQUINONE OXIDOREDUCTASE FROM BOVINE HEART-MITOCHONDRIA
    CROWDER, SE
    RAGAN, CI
    [J]. BIOCHEMICAL JOURNAL, 1977, 165 (02) : 295 - 301
  • [3] ANNONACEOUS ACETOGENINS - AN UPDATED REVIEW
    FANG, XP
    RIESER, MJ
    GU, ZM
    ZHAO, GX
    MCLAUGHLIN, JL
    [J]. PHYTOCHEMICAL ANALYSIS, 1993, 4 (01) : 27 - 48
  • [4] GERAN RI, 1972, CANC CHEMOTHER REP, V3, P1
  • [5] Hatefi Y, 1978, Methods Enzymol, V53, P3
  • [6] BULLATACIN AND BULLATACINONE - 2 HIGHLY POTENT BIOACTIVE ACETOGENINS FROM ANNONA-BULLATA
    HUI, YH
    RUPPRECHT, JK
    LIU, YM
    ANDERSON, JE
    SMITH, DL
    CHANG, CJ
    MCLAUGHLIN, JL
    [J]. JOURNAL OF NATURAL PRODUCTS, 1989, 52 (03): : 463 - 477
  • [7] HUI YH, 1991, THESIS PURDUE U W LA
  • [8] JOLAD SD, 1982, J ORG CHEM, V47, P3151
  • [9] EFFECT OF 2, 4-DINITROPHENOL (DNP) ON OXIDATIVE PHOSPHORYLATION IN RAT LIVER MITOCHONDRIA
    KATYARE, SS
    FATTERPAKER, P
    SREENIVASAN, A
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1971, 144 (01) : 209 - +
  • [10] MOLECULAR-MODE OF ACTION OF ANNONINS
    LONDERSHAUSEN, M
    LEICHT, W
    LIEB, F
    MOESCHLER, H
    WEISS, H
    [J]. PESTICIDE SCIENCE, 1991, 33 (04): : 427 - 438
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