SERUM TNF IN PATIENTS WITH SEVERE MALARIA TREATED BY EXCHANGE-TRANSFUSION

被引:0
作者
LOUTAN, L [1 ]
PLANCHEREL, C [1 ]
SOULIERLAUPER, M [1 ]
PASCUAL, M [1 ]
SUBILIA, L [1 ]
CHEVROLET, JC [1 ]
UNGER, PF [1 ]
GRAU, GE [1 ]
机构
[1] UNIV GENEVA, MED CTR, DEPT PATHOL, CH-1211 GENEVA 4, SWITZERLAND
来源
TROPICAL MEDICINE AND PARASITOLOGY | 1992年 / 43卷 / 04期
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中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
The authors report on three cases of severe P. falciparum malaria successfully treated by iv quinine and exchange transfusion. Serum concentrations of Tumor Necrosis Factor (TNF) were determined before and during treatment. After an initial decrease, serum levels of TNF remained markedly elevated during the first 48 hours despite exchange transfusion. Though exchange transfusion accelerates the elimination of parasites from the blood, it seems to have no immediate effects on reducing serum levels of cytokines such as TNF.
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页码:285 / 286
页数:2
相关论文
共 11 条
[1]   TUMOR-NECROSIS FACTOR AND OTHER CYTOKINES IN CEREBRAL MALARIA - EXPERIMENTAL AND CLINICAL-DATA [J].
GRAU, GE ;
PIGUET, PF ;
VASSALLI, P ;
LAMBERT, PH .
IMMUNOLOGICAL REVIEWS, 1989, 112 :49-70
[2]   TUMOR NECROSIS FACTOR AND DISEASE SEVERITY IN CHILDREN WITH FALCIPARUM-MALARIA [J].
GRAU, GE ;
TAYLOR, TE ;
MOLYNEUX, ME ;
WIRIMA, JJ ;
VASSALLI, P ;
HOMMEL, M ;
LAMBERT, PH .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (24) :1586-1591
[3]   ELEVATED TUMOR NECROSIS FACTOR-ALPHA AND INTERLEUKIN-6 SERUM LEVELS AS MARKERS FOR COMPLICATED PLASMODIUM-FALCIPARUM MALARIA [J].
KERN, P ;
HEMMER, CJ ;
VANDAMME, J ;
GRUSS, HJ ;
DIETRICH, M .
AMERICAN JOURNAL OF MEDICINE, 1989, 87 (02) :139-143
[4]   TNF CONCENTRATION IN FATAL CEREBRAL, NONFATAL CEREBRAL, AND UNCOMPLICATED PLASMODIUM-FALCIPARUM MALARIA [J].
KWIATKOWSKI, D ;
HILL, AVS ;
SAMBOU, I ;
TWUMASI, P ;
CASTRACANE, J ;
MANOGUE, KR ;
CERAMI, A ;
BREWSTER, DR ;
GREENWOOD, BM .
LANCET, 1990, 336 (8725) :1201-1204
[5]  
LOOAREESUWAN S, 1990, Q J MED, V75, P471
[6]   TREATMENT OF SEVERE MALARIA IN THE UNITED-STATES WITH A CONTINUOUS INFUSION OF QUINIDINE GLUCONATE AND EXCHANGE-TRANSFUSION [J].
MILLER, KD ;
GREENBERG, AE ;
CAMPBELL, CC .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (02) :65-70
[7]   ADULT MORTALITY IN DEVELOPING-COUNTRIES [J].
MURRAY, CJL ;
FEACHEM, RGA .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1990, 84 (01) :1-2
[8]  
PHILLIPS P, 1990, REV INFECT DIS, V12, P1100
[9]  
VACHON F, 1990, REAN SOINS INTENS ME, V6, P155
[10]  
WARRELL DA, 1992, SCHWEIZ MED WSCHR, V122, P879