ENHANCED INSULIN SECRETORY RESPONSE TO ACETYLCHOLINE BY PERIFUSED PANCREAS OF 5-DAY-OLD PREOBESE ZUCKER RATS

被引：28

作者：

ATEF, N ^{[1
]}

BRULE, C ^{[1
]}

BIHOREAU, MT ^{[1
]}

KTORZA, A ^{[1
]}

PICON, L ^{[1
]}

PENICAUD, L ^{[1
]}

机构：

[1] UNIV PARIS 07,PHYSIOPATHOL NUTR LAB,CNRS,URA 307,2 PL JUSSIEU,F-75221 PARIS 05,FRANCE

来源：

ENDOCRINOLOGY | 1991年 / 129卷 / 04期

关键词：

D O I：

10.1210/endo-129-4-2219

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The insulin secretion rate in response to different secretagogues and neurotransmittors was studied in perifused pancreases of 5-day-old lean (Fa/Fa) and preobese (fa/fa) Zucker rats. Glucose (16.6 mM) alone or in combination with 20 mM arginine or 5 mM theophylline induced a net stimulation of insulin secretion. This effect was similar in the two groups. By contrast, the stimulatory effect of acetylcholine on glucose-induced insulin secretion was significantly higher in preobese pups than in lean rats. There was also a tendency toward a higher inhibitory effect of norepinephrine on insulin secretion in preobese than in lean rats, but this difference did not reach statistical significance. Together these results demonstrate a normal insulin secretion in response to nutrient secretagogues in preobese fa/fa rats but an enhanced effect of acetylcholine. This latter effect may be related to the changes in the autonomic nervous system activity, which is usually described in obese fa/fa rats.

引用

页码：2219 / 2224

页数：6

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