CONFIRMATION OF LENS HYDRATION BY RAMAN-SPECTROSCOPY

被引：17
作者：
MIZUNO, A
TOSHIMA, S
MORI, Y
机构：
[1] JIKEI UNIV,DEPT OPHTHALMOL,TOKYO 105,JAPAN
[2] JIKEI UNIV,DEPT INTERNAL MED,TOKYO 105,JAPAN
来源：
EXPERIMENTAL EYE RESEARCH | 1990年 / 50卷 / 06期
关键词：
diabetic cataract; lens hydration; Raman spectroscopy; spontaneous diabetes; WBN Kob rat;
D O I：
10.1016/0014-4835(90)90108-7
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Lens hydration was monitored by laser Raman spectroscopy in WBN Kob rats which form spontaneous diabetes at about 1 yr of age and develop cataracts approximately 6 months after the onset of diabetes. Lens hydration in response to chronic hyperglycemic stress in these rats appeared predominantly in the cortical region while the hydration state in the nuclear region was fairly preserved. The 9-month treatment of similarly diabetic rats with the aldose reductase inhibitor Ponalrestat sufficiently suppressed lens hydration in the cortical and nuclear regions. © 1990.
引用
收藏
页码：647 / 649
页数：3
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