Olfactory Dysfunction in Patients with Neuromyelitis Optica

被引：23

作者：

Schmidt, Felix ^{[1
,2
]}

Goektas, Oender ^{[3
]}

Jarius, Sven ^{[4
]}

Wildemann, Brigitte ^{[4
]}

Ruprecht, Klemens ^{[1
,2
]}

Paul, Friedemann ^{[1
,2
,5
,6
,7
]}

Harms, Lutz ^{[1
,2
]}

机构：

[1] Charite Univ Med Berlin, Dept Neurol, Charitepl 1, D-10117 Berlin, Germany

[2] Charite Univ Med Berlin, Clin & Expt Multiple Sclerosis Res Ctr, Berlin, Germany

[3] Charite Univ Med Berlin, Dept Otolaryngol, Berlin, Germany

[4] Heidelberg Univ, Div Mol Neuroimmunol, Dept Neurol, Heidelberg, Germany

[5] Charite Univ Med Berlin, NeuroCure Clin Res Ctr, Berlin, Germany

[6] Charite Univ Med Berlin, Expt & Clin Res Ctr, Berlin, Germany

[7] Max Delbrueck Ctr Mol Med, Berlin, Germany

来源：

MULTIPLE SCLEROSIS INTERNATIONAL | 2013年 / 2013卷

关键词：

D O I：

10.1155/2013/654501

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background. Neuromyelitis optica (NMO) is a severely disabling autoimmune disorder of the CNS, which mainly affects the optic nerves and spinal cord. However, recent studies have shown that extra-opticospinal are more common in NMO than previously thought. Objective. To investigate olfactory function (OF) in patients with neuromyelitis optica (NMO) versus healthy controls (HC). Methods. Psychophysical testing of the orthonasal OF was performed using the Threshold-Discrimination-Identification test (TDI), measuring different qualities of olfaction, in 10 unselected NMO patients and 10 HC. Results. Five of 10 NMO patients (50%) showed hyposmia, while all 10 HC were normosmic. Moreover, NMO patients had significantly lower mean TDI-scores compared to HC, based on a poorer performance in both the Discrimination and the Identification subtests. Conclusions. Our results suggest that hyposmia might be part of the expanding clinical spectrum of NMO.

引用

页数：4

共 16 条

[1] Immunolocalization of water channel aquaporins in the nasal olfactory mucosa [J].

Ablimit, A ;

Matsuzaki, T ;

Tajika, Y ;

Aoki, T ;

Hagiwara, H ;

Takata, K .

ARCHIVES OF HISTOLOGY AND CYTOLOGY, 2006, 69 (01) :1-12

[2] Olfactory dysfunction in multiple sclerosis: Relation to longitudinal changes in plaque numbers in central olfactory structures [J].

Doty, RL ;

Li, C ;

Mannon, LJ ;

Yousem, DM .

NEUROLOGY, 1999, 53 (04) :880-882

[3]

Doty RL, 1997, NEW ENGL J MED, V337, P507

[4] Normative data for the "Sniffin' Sticks" including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects [J].

Hummel, T. ;

Kobal, G. ;

Gudziol, H. ;

Mackay-Sim, A. .

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2007, 264 (03) :237-243

[5] Standardized method for the detection of antibodies to aquaporin-4 based on a highly sensitive immunofluorescence assay employing recombinant target antigen [J].

Jarius, S. ;

Probst, C. ;

Borowski, K. ;

Franciotta, D. ;

Wildemann, B. ;

Stoecker, W. ;

Wandinger, K. P. .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2010, 291 (1-2) :52-56

[6]

Jarius S., BRAIN PATHO IN PRESS

[7] Mechanisms of disease: aquaporin-4 antibodies in neuromyelitis optica [J].

Jarius, Sven ;

Paul, Friedemann ;

Franciotta, Diego ;

Waters, Patrick ;

Zipp, Frauke ;

Hohlfeld, Reinhard ;

Vincent, Angela ;

Wildemann, Brigitte .

NATURE CLINICAL PRACTICE NEUROLOGY, 2008, 4 (04) :202-214

[8] The history of neuromyelitis optica [J].

Jarius, Sven ;

Wildemann, Brigitte .

JOURNAL OF NEUROINFLAMMATION, 2013, 10

[9] Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients [J].

Jarius, Sven ;

Ruprecht, Klemens ;

Wildemann, Brigitte ;

Kuempfel, Tania ;

Ringelstein, Marius ;

Geis, Christian ;

Kleiter, Ingo ;

Kleinschnitz, Christoph ;

Berthele, Achim ;

Brettschneider, Johannes ;

Hellwig, Kerstin ;

Hemmer, Bernhard ;

Linker, Ralf A. ;

Lauda, Florian ;

Mayer, Christoph A. ;

Tumani, Hayrettin ;

Melms, Arthur ;

Trebst, Corinna ;

Stangel, Martin ;

Marziniak, Martin ;

Hoffmann, Frank ;

Schippling, Sven ;

Faiss, Juergen H. ;

Neuhaus, Oliver ;

Ettrich, Barbara ;

Zentner, Christian ;

Guthke, Kersten ;

Hofstadt-van Oy, Ulrich ;

Reuss, Reinhard ;

Pellkofer, Hannah ;

Ziemann, Ulf ;

Kern, Peter ;

Wandinger, Klaus P. ;

Bergh, Florian Then ;

Boettcher, Tobias ;

Langel, Stefan ;

Liebetrau, Martin ;

Rommer, Paulus S. ;

Niehaus, Sabine ;

Muench, Christoph ;

Winkelmann, Alexander ;

Zettl U, Uwe K. ;

Metz, Imke ;

Veauthier, Christian ;

Sieb, Joern P. ;

Wilke, Christian ;

Hartung, Hans P. ;

Aktas, Orhan ;

Paul, Friedemann .

JOURNAL OF NEUROINFLAMMATION, 2012, 9

[10] AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance [J].

Jarius, Sven ;

Wildemann, Brigitte .

NATURE REVIEWS NEUROLOGY, 2010, 6 (07) :383-392

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