MATERNAL SERUM CREATINE-KINASE AS A BIOCHEMICAL MARKER OF TUBAL PREGNANCY

Objective: To evaluate the role of serum creatine kinase as a possible marker for diagnosis of tubal pregnancy. Methods: Five groups of patients were included in this prospective study: group A, 20 patients with tubal pregnancies; group B, 20 patients with missed abortions; group C, 20 patients with pelvic inflammatory disease; group D, 10 patients with acute appendicitis; group E (controls), 20 patients with normal pregnancies matched for age and gestation. Total creatine kinase levels were measured in the serum of all five groups. Results: Creatine kinase levels were found to be greater than or equal to 75 IU/l in all patients with tubal pregnancies, which was significantly higher than in the other four groups (P < 0.0001). Conclusion: Our results indicate that maternal serum creatine kinase can be an important biochemical marker in suspected tubal pregnancy.