THROMBOCYTOPENIA IN C-MPL-DEFICIENT MICE

被引：562

作者：

GURNEY, AL

CARVERMOORE, K

DESAUVAGE, FJ

MOORE, MW

机构：

[1] GENENTECH INC,DEPT CELL GENET,S SAN FRANCISCO,CA 94080

[2] GENENTECH INC,DEPT MOLEC BIOL,S SAN FRANCISCO,CA 94080

来源：

SCIENCE | 1994年 / 265卷 / 5177期

关键词：

D O I：

10.1126/science.8073287

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Thrombopoietin (TPO) is a cytokine that is involved in the regulation of platelet production. The receptor for TPO is c-Mpl. To further investigate the role and specificity of this receptor in regulating megakaryocytopoiesis, c-mpl-deficient mice were generated by gene targeting. The c-mpl(-/-) mice had an 85 percent decrease in their number of platelets and megakaryocytes but had normal amounts of other hematopoietic cell types. These mice also had increased concentrations of circulating TPO. These results show that c-mpl specifically regulates megakaryocytopoiesis and thrombopoiesis through activation by its ligand TPO.

引用

页码：1445 / 1447

页数：3

共 16 条

[1]

[Anonymous], 1987, TERATOCARCINOMA EMBR

[2]

CARVERMOORE K, UNPUB

[3] STIMULATION OF MEGAKARYOCYTOPOIESIS AND THROMBOPOIESIS BY THE C-MPL LIGAND [J].

DESAUVAGE, FJ ;

HASS, PE ;

SPENCER, SD ;

MALLOY, BE ;

GURNEY, AL ;

SPENCER, SA ;

DARBONNE, WC ;

HENZEL, WJ ;

WONG, SC ;

KUANG, WJ ;

OLES, KJ ;

HULTGREN, B ;

SOLBERG, LA ;

GOEDDEL, DV ;

EATON, DL .

NATURE, 1994, 369 (6481) :533-538

[4] TRANSGENESIS BY MEANS OF BLASTOCYST-DERIVED EMBRYONIC STEM-CELL LINES [J].

GOSSLER, A ;

DOETSCHMAN, T ;

KORN, R ;

SERFLING, E ;

KEMLER, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (23) :9065-9069

[5]

GURNEY AL, UNPUB

[6] ASSAY OF AN ACTIVITY IN THE SERUM OF PATIENTS WITH DISORDERS OF THROMBOPOIESIS THAT STIMULATES FORMATION OF MEGAKARYOCYTIC COLONIES [J].

HOFFMAN, R ;

MAZUR, E ;

BRUNO, E ;

FLOYD, V .

NEW ENGLAND JOURNAL OF MEDICINE, 1981, 305 (10) :533-538

[7] PROMOTION OF MEGAKARYOCYTE PROGENITOR EXPANSION AND DIFFERENTIATION BY THE C-MPL LIGAND THROMBOPOIETIN [J].

KAUSHANSKY, K ;

LOK, S ;

HOLLY, RD ;

BROUDY, VC ;

LIN, N ;

BAILEY, MC ;

FORSTROM, JW ;

BUDDLE, MM ;

OORT, PJ ;

HAGEN, FS ;

ROTH, GJ ;

PAPAYANNOPOULOU, T ;

FOSTER, DC .

NATURE, 1994, 369 (6481) :568-571

[8] CLONING AND EXPRESSION OF MURINE THROMBOPOIETIN CDNA AND STIMULATION OF PLATELET PRODUCTION IN-VIVO [J].

LOK, S ;

KAUSHANSKY, K ;

HOLLY, RD ;

KUIJPER, JL ;

LOFTONDAY, CE ;

OORT, PJ ;

GRANT, FJ ;

HEIPEL, MD ;

BURKHEAD, SK ;

KRAMER, JM ;

BELL, LA ;

SPRECHER, CA ;

BLUMBERG, H ;

JOHNSON, R ;

PRUNKARD, D ;

CHING, AFT ;

MATHEWES, SL ;

BAILEY, MC ;

FORSTROM, JW ;

BUDDLE, MM ;

OSBORN, SG ;

EVANS, SJ ;

SHEPPARD, PO ;

PRESNELL, SR ;

OHARA, PJ ;

HAGEN, FS ;

ROTH, GJ ;

FOSTER, DC .

NATURE, 1994, 369 (6481) :565-568

[9] THE MOUSE PGK-1 GENE PROMOTER CONTAINS AN UPSTREAM ACTIVATOR SEQUENCE [J].

MCBURNEY, MW ;

SUTHERLAND, LC ;

ADRA, CN ;

LECLAIR, B ;

RUDNICKI, MA ;

JARDINE, K .

NUCLEIC ACIDS RESEARCH, 1991, 19 (20) :5755-5761

[10]

METHIA N, 1993, BLOOD, V82, P1395

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