ATOPIC ASTHMA CAUSED BY CANDIDA-ALBICANS ACID PROTEASE - CASE-REPORTS

被引：22
|
作者：
AKIYAMA, K [1 ]
SHIDA, T [1 ]
YASUEDA, H [1 ]
MITA, H [1 ]
YAMAMOTO, T [1 ]
YAMAGUCHI, H [1 ]
机构：
[1] TEIKYO UNIV,TOKYO 173,JAPAN
来源：
ALLERGY | 1994年 / 49卷 / 09期
关键词：
ACID PROTEASE; ATOPIC ASTHMA; BRONCHIAL PROVOCATION TEST; CANDIDA ALBICANS; CONJUNCTIVAL TEST; HISTAMINE RELEASE TEST; IGE ANTIBODY; SKIN TEST;
D O I：
10.1111/j.1398-9995.1994.tb02102.x
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Two cases of atopic asthma caused by acid protease produced by Candida albicans are reported. Both patients had high levels of serum IgE antibodies against the acid protease and showed positive conjunctival and immediate bronchial responses when challenged with the protease. Significant histamine release was detected in both patients when their peripheral leukocytes were challenged with the protease antigen. These findings clearly showed that C. albicans acid protease is the causative allergen of atopic asthma.
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页码：778 / 781
页数：4
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