INTERLEUKIN-11 INHIBITS BONE-FORMATION IN-VITRO

被引：56
|
作者：
HUGHES, FJ
HOWELLS, GL
机构：
[1] UNIV LONDON LONDON HOSP,COLL MED,DEPT ORAL MED & PERIODONTOL,TURNER ST,LONDON E1 2AD,ENGLAND
[2] UNIV LONDON LONDON HOSP,COLL MED,DEPT ORAL PATHOL,LONDON E1 2AD,ENGLAND
来源：
CALCIFIED TISSUE INTERNATIONAL | 1993年 / 53卷 / 05期
关键词：
D O I：
10.1007/BF01351844
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The effects of interleukin-11(IL-11) on the differentiation of osteoblast precursors was tested using a bone nodule forming assay in rat calvaria cell cultures. IL-11 caused a dose dependent inhibition of nodule formation, with 500U/ml IL-11 resulting in complete inhibition of nodule formation. IL-11 also caused a reduction in alkaline phosphatase expression in these cultures. These effects are similar to, but more potent than, the actions of IL-6 on these cells. These results indicate that IL-11 is an osteotropic cytokine and suggest that IL-11 may be an important inhibitor of bone formation in health and disease.
引用
收藏
页码：362 / 364
页数：3
相关论文
共 50 条
  • [1] INTERLEUKIN-6 INHIBITS BONE-FORMATION INVITRO
    HUGHES, FJ
    HOWELLS, GL
    BONE AND MINERAL, 1993, 21 (01): : 21 - 28
  • [2] The cellular actions of interleukin-11 on bone resorption in vitro
    Hill, PA
    Tumber, A
    Papaioannou, S
    Meikle, MC
    ENDOCRINOLOGY, 1998, 139 (04) : 1564 - 1572
  • [3] BONE-FORMATION IS LOCATION-SPECIFIC IN-VITRO
    GRAY, C
    BOYDE, A
    JONES, SJ
    JOURNAL OF BONE AND MINERAL RESEARCH, 1995, 10 : S408 - S408
  • [4] EFFECTS OF CHRONIC GALLIUM TREATMENT ON BONE-FORMATION IN-VITRO
    PAN, LC
    GUIDON, PT
    BOCKMAN, RS
    JOURNAL OF BONE AND MINERAL RESEARCH, 1993, 8 : S306 - S306
  • [5] EFFECTS OF RECOMBINANT HUMAN INTERLEUKIN-11 (RHIL-11) ON MURINE HEMATOPOIESIS IN-VITRO
    DU, XX
    WILLIAMS, DA
    BLOOD, 1993, 82 (10) : A319 - A319
  • [6] Effects of interleukin-11 on bone.
    Shih, C
    Yen, CC
    JOURNAL OF BONE AND MINERAL RESEARCH, 1997, 12 : S340 - S340
  • [7] INTERLEUKIN-11 INDIRECTLY INDUCES PROLIFERATION AND ENDOMITOSIS OF IMMATURE HUMAN MEGAKARYOCYTES IN-VITRO
    ANGCHAISUKSIRI, P
    CARLSON, PL
    DAY, EB
    DESSYPRIS, EN
    BLOOD, 1994, 84 (10) : A683 - A683
  • [8] The cytokine interleukin-11 crucially links bone formation, remodeling and resorption
    Kespohl, Birte
    Schumertl, Tim
    Bertrand, Jessica
    Lokau, Juliane
    Garbers, Christoph
    CYTOKINE & GROWTH FACTOR REVIEWS, 2021, 60 : 18 - 27
  • [9] Interleukin-11 inhibits macrophage interleukin-12 production
    Leng, SX
    Elias, JA
    JOURNAL OF IMMUNOLOGY, 1997, 159 (05): : 2161 - 2168
  • [10] EFFECTS OF INSULIN ON IN-VITRO BONE-FORMATION IN FETAL-RAT PARIETAL BONE
    YANO, H
    OHYA, K
    AMAGASA, T
    ENDOCRINE JOURNAL, 1994, 41 (03) : 293 - 300
12345