INFECTION OF MACACA-NEMESTRINA BY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1

被引：161
作者：
AGY, MB
FRUMKIN, LR
COREY, L
COOMBS, RW
WOLINSKY, SM
KOEHLER, J
MORTON, WR
KATZE, MG
机构：
[1] UNIV WASHINGTON,DEPT MED,SEATTLE,WA 98195
[2] UNIV WASHINGTON,DEPT LAB MED,SEATTLE,WA 98195
[3] UNIV WASHINGTON,DEPT MICROBIOL,SEATTLE,WA 98195
[4] UNIV WASHINGTON,REG PRIMATE RES CTR,SEATTLE,WA 98195
[5] UNIV WASHINGTON,DEPT BIOL STRUCT,SEATTLE,WA 98195
[6] NORTHWESTERN UNIV,DEPT MED,CHICAGO,IL 60611
来源：
SCIENCE | 1992年 / 257卷 / 5066期
关键词：
D O I：
10.1126/science.1621083
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
After observations that Macaca nemestrina were exceptionally susceptible to simian immunodeficiency virus and human immunodeficiency virus type-2 (HIV-2), studies of HIV-1 replication were initiated. Several strains of HIV-1, including a recent patient isolate, replicated in vitro in peripheral blood mononuclear cells (PBMCs) and in CD4-positive M. nemestrina lymphocytes in a CD4-dependent fashion. Eight animals were subsequently inoculated with either cell-associated or cell-free suspensions of HIV-1. All animals had HIV-1 isolated by cocultivation, had HIV-1 DNA in their PBMCs as shown by polymerase chain reaction, and experienced sustained seroconversion to a broad spectrum of HIV-1 proteins. Macaca nemestrina is an animal model of HIV-1 infections that provides opportunities for evaluating the pathogenesis of acute HIV-1 replication and candidate vaccines and therapies.
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收藏
页码：103 / 106
页数：4
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