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TUMOR-NECROSIS-FACTOR (TNF-ALPHA) AND NEUROLOGICAL DISORDERS IN HIV-INFECTION
被引:40
|作者:
MASTROIANNI, CM
[1
]
PAOLETTI, F
[1
]
VALENTI, C
[1
]
VULLO, V
[1
]
JIRILLO, E
[1
]
DELIA, S
[1
]
机构:
[1] UNIV BARI,I-70124 BARI,ITALY
来源:
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
|
1992年
/
55卷
/
03期
关键词:
D O I:
10.1136/jnnp.55.3.219
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
Tumour necrosis factor (TNF-alpha) concentrations were determined in the CSF from 42 HIV-infected patients, with or without CNS involvement. In addition, 14 subjects with various neurological disorders but without HIV antibodies were included as controls. Raised CSF concentrations of TNF-alpha (> 40 ng/l) were detected both in patients with AIDS dementia complex (ADC) (6/9) and with CNS opportunistic infections (10/19) and, less commonly, in HIV infected subjects without CNS diseases (2/14) and in anti-HIV negative controls (1/14). The highest CSF concentrations of TNF-alpha (> 100 ng/l), however, were found in seven out of eight patients with cryptococcal meningitis. Although a role for TNF-alpha in demyelinating lesions associated with ADC has been suggested, our results indicate that a clear elevation of TNF-alpha in the CSF from HIV positive patients mostly occurs in acute inflammatory disorders, such as cryptococcal meningitis.
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页码:219 / 221
页数:3
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