TUMOR-NECROSIS-FACTOR (TNF-ALPHA) AND NEUROLOGICAL DISORDERS IN HIV-INFECTION

被引:40
|
作者
MASTROIANNI, CM [1 ]
PAOLETTI, F [1 ]
VALENTI, C [1 ]
VULLO, V [1 ]
JIRILLO, E [1 ]
DELIA, S [1 ]
机构
[1] UNIV BARI,I-70124 BARI,ITALY
来源
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1992年 / 55卷 / 03期
关键词
D O I
10.1136/jnnp.55.3.219
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Tumour necrosis factor (TNF-alpha) concentrations were determined in the CSF from 42 HIV-infected patients, with or without CNS involvement. In addition, 14 subjects with various neurological disorders but without HIV antibodies were included as controls. Raised CSF concentrations of TNF-alpha (> 40 ng/l) were detected both in patients with AIDS dementia complex (ADC) (6/9) and with CNS opportunistic infections (10/19) and, less commonly, in HIV infected subjects without CNS diseases (2/14) and in anti-HIV negative controls (1/14). The highest CSF concentrations of TNF-alpha (> 100 ng/l), however, were found in seven out of eight patients with cryptococcal meningitis. Although a role for TNF-alpha in demyelinating lesions associated with ADC has been suggested, our results indicate that a clear elevation of TNF-alpha in the CSF from HIV positive patients mostly occurs in acute inflammatory disorders, such as cryptococcal meningitis.
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页码:219 / 221
页数:3
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