CLUSTERING OF EXTENSIVE SOMATIC MUTATIONS IN THE VARIABLE REGION OF AN IMMUNOGLOBULIN HEAVY-CHAIN GENE FROM A HUMAN B-CELL LYMPHOMA

被引:292
作者
CLEARY, ML [1 ]
MEEKER, TC [1 ]
LEVY, S [1 ]
LEE, E [1 ]
TRELA, M [1 ]
SKLAR, J [1 ]
LEVY, R [1 ]
机构
[1] STANFORD UNIV,MED CTR,SCH MED,DEPT MED,STANFORD,CA 94305
关键词
D O I
10.1016/0092-8674(86)90488-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:97 / 106
页数:10
相关论文
共 44 条
[21]   ANTIBODY DIVERSITY - SOMATIC HYPER-MUTATION OF REARRANGED VH GENES [J].
KIM, S ;
DAVIS, M ;
SINN, E ;
PATTEN, P ;
HOOD, L .
CELL, 1981, 27 (03) :573-581
[22]  
LEDER P, 1980, PROGR IMMUNOLOGY, V4, P34
[23]   MOLECULAR-BASIS OF A MOUSE STRAIN-SPECIFIC ANTI-HAPTEN RESPONSE [J].
LOH, DY ;
BOTHWELL, ALM ;
WHITESCHARF, ME ;
IMANISHIKARI, T ;
BALTIMORE, D .
CELL, 1983, 33 (01) :85-93
[24]   SEQUENCES OF 5 POTENTIAL RECOMBINATION SITES ENCODED CLOSE TO AN IMMUNOGLOBULIN K-CONSTANT REGION GENE [J].
MAX, EE ;
SEIDMAN, JG ;
LEDER, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (07) :3450-3454
[25]   GENERATION OF ANTIBODY DIVERSITY IN THE IMMUNE-RESPONSE OF BALB-C MICE TO INFLUENZA-VIRUS HEMAGGLUTININ [J].
MCKEAN, D ;
HUPPI, K ;
BELL, M ;
STAUDT, L ;
GERHARD, W ;
WEIGERT, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (10) :3180-3184
[26]   EMERGENCE OF IDIOTYPE VARIANTS DURING TREATMENT OF B-CELL LYMPHOMA WITH ANTI-IDIOTYPE ANTIBODIES [J].
MEEKER, T ;
LOWDER, J ;
CLEARY, ML ;
STEWART, S ;
WARNKE, R ;
SKLAR, J ;
LEVY, R .
NEW ENGLAND JOURNAL OF MEDICINE, 1985, 312 (26) :1658-1665
[27]   A CLINICAL-TRIAL OF ANTI-IDIOTYPE THERAPY FOR B-CELL MALIGNANCY [J].
MEEKER, TC ;
LOWDER, J ;
MALONEY, DG ;
MILLER, RA ;
THIELEMANS, K ;
WARNKE, R ;
LEVY, R .
BLOOD, 1985, 65 (06) :1349-1363
[28]   TREATMENT OF B-CELL LYMPHOMA WITH MONOCLONAL ANTI-IDIOTYPE ANTIBODY [J].
MILLER, RA ;
MALONEY, DG ;
WARNKE, R ;
LEVY, R .
NEW ENGLAND JOURNAL OF MEDICINE, 1982, 306 (09) :517-522
[29]   STRUCTURAL-ANALYSIS OF MONOCLONAL ANTI-ARSONATE ANTIBODIES - IDIOTYPIC SPECIFICITIES ARE DETERMINED BY THE HEAVY-CHAIN [J].
MILNER, ECB ;
CAPRA, JD .
MOLECULAR IMMUNOLOGY, 1983, 20 (01) :39-46
[30]   LAMBDOID PHAGES THAT SIMPLIFY RECOVERY OF INVITRO RECOMBINANTS [J].
MURRAY, NE ;
BRAMMAR, WJ ;
MURRAY, K .
MOLECULAR & GENERAL GENETICS, 1977, 150 (01) :53-61