IMMUNOLOGICAL PRIMING WITH RECOMBINANT HEPATITIS-A VIRUS CAPSID PROTEINS PRODUCED IN ESCHERICHIA-COLI

被引：22

作者：

POWDRILL, TF ^{[1
]}

JOHNSTON, JM ^{[1
]}

机构：

[1] BURROUGHS WELLCOME CO,DEPT CLIN IMMUNOL,RES TRIANGLE PK,NC 27709

来源：

JOURNAL OF VIROLOGY | 1991年 / 65卷 / 05期

关键词：

D O I：

10.1128/JVI.65.5.2686-2690.1991

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hepatitis A virus capsid proteins (VP0, VP3, and VP1) have been synthesized in Escherichia coli for use in antigenic and immunogenic analyses. Rabbits immunized with each of these individual recombinant capsid proteins developed a rapid neutralizing antibody response when subsequently challenged with a subimmunogenic dose of whole virus.

引用

页码：2686 / 2690

页数：5

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