Challenges and opportunities in dermal/transdermal delivery

被引：422
作者：
Paudel, Kalpana S. [1 ]
Milewski, Mikolaj [1 ]
Swadley, Courtney L. [1 ]
Brogden, Nicole K. [1 ]
Ghosh, Priyanka [1 ]
Stinchcomb, Audra L. [1 ]
机构：
[1] Univ Kentucky, Coll Pharm, Lexington, KY 40536 USA
来源：
THERAPEUTIC DELIVERY | 2010年 / 1卷 / 01期
关键词：
D O I：
10.4155/TDE.10.16
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Transdermal drug delivery is an exciting and challenging area. There are numerous transdermal delivery systems currently available on the market. However, the transdermal market still remains limited to a narrow range of drugs. Further advances in transdermal delivery depend on the ability to overcome the challenges faced regarding the permeation and skin irritation of the drug molecules. Emergence of novel techniques for skin permeation enhancement and development of methods to lessen skin irritation would widen the transdermal market for hydrophilic compounds, macromolecules and conventional drugs for new therapeutic indications. As evident from the ongoing clinical trials of a wide variety of drugs for various clinical conditions, there is a great future for transdermal delivery of drugs.
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页码：109 / 131
页数：23
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