NEONATAL THYMECTOMY DIMINISHES RENAL IGA DEPOSITION IN IGA NEPHROPATHY-PRONE DDY MICE

被引:5
作者
NAGASAWA, R
MITARAI, T
UTSUNOMIYA, Y
YOSHIDA, H
KITAMURA, M
YAMURA, W
MARUYAMA, N
ISODA, K
SAKAI, O
机构
[1] JIKEI UNIV, SCH MED, DEPT INTERNAL MED, TOKYO, JAPAN
[2] TOKYO WOMENS MED COLL, CTR KIDNEY, DEPT MED, TOKYO, TOKYO, JAPAN
[3] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL, DEPT PATHOL, TOKYO, TOKYO, JAPAN
关键词
DDY MOUSE; IGA NEPHROPATHY; NEONATAL THYMECTOMY; MESANGIAL IGA DEPOSITION; CYTOKINE;
D O I
10.1159/000187831
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
To understand the role of thymus-derived T cells in the development of IgA nephropathy (IgAN), we performed neonatal thymectomies on ddY mice, in which this disease occurs spontaneously. Although these thymectomized mice developed a renal lesion closely resembling that typical of IgAN, the extent of their mesangial IgA deposition was significantly milder than in control sham-operated mice. The immunological mechanisms responsible for curbing this mesangial deposition of IgA were then analyzed. The percentage of splenic T cells and the magnitude of mitogenic responses both decreased markedly in thymectomized compared with control mice. These results suggested the hypofunction of thymus-derived T cells. However, serum IgA levels were almost identical in both groups. Furthermore, sera from both groups contained similar amounts of macromolecular IgA, of the type formerly eluted from the affected glomeruli of patients with IgAN. These results strongly indicate that thymus-derived T cells or their products determine the amount of IgA deposited in the kidneys of ddY mice.
引用
收藏
页码:326 / 332
页数:7
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