TNF-ALPHA INCREASES THE FREQUENCY OF SPONTANEOUS MINIATURE SYNAPTIC CURRENTS IN CULTURED RAT HIPPOCAMPAL-NEURONS

被引：50
|
作者：
GRASSI, F
MILEO, AM
MONACO, L
PUNTURIERI, A
SANTONI, A
EUSEBI, F
机构：
[1] UNIV ROMA LA SAPIENZA,DIPARTIMENTO MED SPERIMENTALE,I-00161 ROME,ITALY
[2] UNIV ROMA LA SAPIENZA,IST ISTOL,I-00161 ROME,ITALY
来源：
BRAIN RESEARCH | 1994年 / 659卷 / 1-2期
关键词：
TUMOR NECROSIS FACTOR-ALPHA; TNF RECEPTOR; CULTURED HIPPOCAMPAL NEURON; MINIATURE SYNAPTIC CURRENT; SPONTANEOUS SYNAPTIC ACTIVITY;
D O I：
10.1016/0006-8993(94)90883-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Tumor necrosis factor-alpha (TNF-alpha) is a cytokine secreted by activated astrocytes and is known to alter evoked synaptic activity in slices of adult rat hippocampus. In this paper we show that TNF-alpha increases the frequency of spontaneous miniature synaptic currents in cultured hippocampal neurons, acting at nanomolar concentrations. In addition, we show that the mRNA for the 55 kDa TNF-alpha receptor (TNF-R1) is detected in embryonic rat hippocampal cultures, as well as in acutely dissected embryonic and adult rat hippocampi. Possible transduction pathways mediating the TNF-alpha effect are discussed.
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页码：226 / 230
页数：5
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