EXTENSIVE NETWORK OF PHF-TAU-RICH DYSTROPHIC NEURITES PERMEATES NEOCORTEX AND NEARLY ALL NEURITIC AND DIFFUSE AMYLOID PLAQUES IN ALZHEIMER-DISEASE

被引：53

作者：

SCHMIDT, ML ^{[1
]}

DIDARIO, AG ^{[1
]}

LEE, VMY ^{[1
]}

TROJANOWSKI, JQ ^{[1
]}

机构：

[1] UNIV PENN, SCH MED, DEPT PATHOL & LAB MED, DIV ANAT PATHOL, PHILADELPHIA, PA 19104 USA

来源：

FEBS LETTERS | 1994年 / 344卷 / 01期

关键词：

ALZHEIMERS DISEASE; SENILE PLAQUE; NEURONAL CYTOSKELETON;

D O I：

10.1016/0014-5793(94)00259-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previous studies demonstrated paired helical filament tau (PHF tau) in neuritic but not diffuse beta-amyloid (AP) plaques in Alzheimer's disease (AD). Re-examination of amyloid deposits with antibodies to A beta and PHF tau by conventional and confocal microscopy using double label immunohistochemistry showed that PHF tau is a component of both diffuse and neuritic plaques in AD, Unlike controls, a dense network of PHF tau positive dystrophic neurites extended throughout the AD neocortex permeating nearly all neuritic and diffuse plaques. Thus, PHF tau-rich dystrophic neurites are common components of neuritic and diffuse plaques in AD neocortex.

引用

页码：69 / 73

页数：5