THE ROLE OF MYCOBACTERIUM-TUBERCULOSIS IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS

被引：14

作者：

NAMER, IJ ^{[1
]}

STEIBEL, J ^{[1
]}

POULET, P ^{[1
]}

MAUSS, Y ^{[1
]}

MOHR, M ^{[1
]}

CHAMBRON, J ^{[1
]}

机构：

[1] FAC MED STRASBOURG,INST PATHOL ANAT,STRASBOURG,FRANCE

来源：

EUROPEAN NEUROLOGY | 1994年 / 34卷 / 04期

关键词：

EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; BLOOD-BRAIN BARRIER; MYCOBACTERIUM TUBERCULOSIS; MAGNETIC RESONANCE IMAGING;

D O I：

10.1159/000117043

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Various detergents used in preparative membrane protein chemistry were added to a complete Freund's adjuvant/water emulsion in order to increase the solubility and/or immunologic availability of the Mycobacterium tuberculosis membrane and to explain its role in blood-brain barrier (BBB) permeability. Magnetic resonance imaging was used for in vivo determination of the BBB breakdown and cerebral edema. The results showed that with 1% 10 tridecyl ether, which increases emulsion stability, abundant BBB breakdown and cerebral edema were observed, similar to those encountered in experimental allergic encephalomyelitis (EAE). We suggest that the immunologic response triggered off by M. tuberculosis largely contributes to the BBB permeability changes observed during EAE, probably by an action on the endothelial cells of the cerebral blood vessels.

引用

页码：224 / 227

页数：4

共 7 条

[1] FREUND J, 1956, Bibl Tuberc, P130
[2] HUMORAL IMMUNITY IN CHRONIC RELAPSING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS - THE MAJOR OLIGOCLONAL IGG BANDS ARE ANTIBODIES TO MYCOBACTERIA
GLYNN, P
WEEDON, D
EDWARDS, J
SUCKLING, AJ
CUZNER, ML
[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 1982, 57 (2-3) : 369 - 384
[3] LASSMANN H, 1991, REV NEUROL-FRANCE, V147, P763
[4] NAMER IJ, 1992, MAGNET RESON MED, V24, P325
[5] BLOOD-BRAIN-BARRIER BREAKDOWN IN MBP-SPECIFIC T-CELL INDUCED EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS - A QUANTITATIVE INVIVO MRI STUDY
NAMER, IJ
STEIBEL, J
POULET, P
ARMSPACH, JP
MOHR, M
MAUSS, Y
CHAMBRON, J
[J]. BRAIN, 1993, 116 : 147 - 159
[6] RAINE CS, 1984, LAB INVEST, V50, P608
[7] THE EFFECT OF FREUND ADJUVANTS ON BLOOD-CEREBROSPINAL FLUID BARRIER PERMEABILITY
REIBER, H
SUCKLING, AJ
RUMSBY, MG
[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 1984, 63 (01) : 55 - 61

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