GENOMIC ORGANIZATION AND LOCALIZATION OF THE GENE ENCODING HUMAN PREPROGALANIN

被引：38
|
作者：
EVANS, H
BAUMGARTNER, M
SHINE, J
HERZOG, H
机构：
[1] UNIV INNSBRUCK, INST BIOCHEM, A-6020 INNSBRUCK, AUSTRIA
[2] ST VINCENTS HOSP, GARVAN INST MED RES, SYDNEY, NSW 2010, AUSTRALIA
来源：
GENOMICS | 1993年 / 18卷 / 03期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/S0888-7543(11)80002-9
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
An approximately 35-kb region of genomic DNA encoding the human preprogalanin gene including 5‘ and 3‘ flanking sequences has been cloned and characterized. Exons and flanking introns were sequenced to determine the structural organization of the gene. The gene spans 6.5 kb, with the first exon encoding only the 5‘ untranslated sequence. The coding region of preprogalanin and the 3‘ untranslated sequence is divided into five exons. Using high-resolution fluorescence in situ hybridization, the position of the single human preprogalanin gene was localized to chromosome 11q13.3-q13.5. Several oncogenes have been mapped to this region, which is also the breakpoint for the translocation t(11;14)(q13;q32) in chronic lymphocytic leukemia and diffuse B-cell lymphoma. © 1994 Academic Press. All rights reserved.
引用
收藏
页码：473 / 477
页数：5
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