SELECTIVITY OF THE PARKINSONIAN NEUROTOXIN MPTP - TOXIC METABOLITE MPP+ BINDS TO NEUROMELANIN

被引:268
作者
DAMATO, RJ
LIPMAN, ZP
SNYDER, SH
机构
[1] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,725 N WOLFE ST,BALTIMORE,MD 21205
[2] JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21205
[3] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI,BALTIMORE,MD 21205
关键词
D O I
10.1126/science.3080808
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:987 / 989
页数:3
相关论文
共 28 条
[1]  
BJORKLUND A, 1984, HDB CHEM NEUROANATOM, V2, P89
[2]   A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].
BURNS, RS ;
CHIUEH, CC ;
MARKEY, SP ;
EBERT, MH ;
JACOBOWITZ, DM ;
KOPIN, IJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14) :4546-4550
[3]  
BURNS RS, 1984, CAN J NEUROL SCI, V11, P166
[4]   ETIOLOGY OF PARKINSONS-DISEASE [J].
CALNE, DB ;
LANGSTON, JW .
LANCET, 1983, 2 (8365) :1457-1459
[5]   POTENTIAL BIOACTIVATION PATHWAYS FOR THE NEUROTOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) [J].
CASTAGNOLI, N ;
CHIBA, K ;
TREVOR, AJ .
LIFE SCIENCES, 1985, 36 (03) :225-230
[6]  
COTZIAS GC, 1964, FED PROC, V23, P713
[7]   NEURONAL PIGMENTS - SPECTROSCOPIC CHARACTERIZATION OF HUMAN-BRAIN MELANIN [J].
DAS, KC ;
ABRAMSON, MB ;
KATZMAN, R .
JOURNAL OF NEUROCHEMISTRY, 1978, 30 (03) :601-606
[8]   CHRONIC PARKINSONISM SECONDARY TO INTRAVENOUS-INJECTION OF MEPERIDINE ANALOGS [J].
DAVIS, GC ;
WILLIAMS, AC ;
MARKEY, SP ;
EBERT, MH ;
CAINE, ED ;
REICHERT, CM ;
KOPIN, IJ .
PSYCHIATRY RESEARCH, 1979, 1 (03) :249-254
[9]   NEUROCHEMICAL AND HISTOCHEMICAL CHARACTERIZATION OF NEUROTOXIC EFFECTS OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE ON BRAIN CATECHOLAMINE NEURONS IN THE MOUSE [J].
HALLMAN, H ;
LANGE, J ;
OLSON, L ;
STROMBERG, I ;
JONSSON, G .
JOURNAL OF NEUROCHEMISTRY, 1985, 44 (01) :117-127
[10]  
HAMBERGER B, 1967, ACTA PHYSIOL SCAND S, V295, P1