REMOVAL OF HEPATITIS-B SURFACE-ANTIGEN (HBSAG) FROM PLASMA FRACTIONS

被引：0

作者：

JOHNSON, AJ ^{[1
]}

SEMAR, M ^{[1
]}

NEWMAN, J ^{[1
]}

HARRIS, RB ^{[1
]}

BRANDT, D ^{[1
]}

MIDDLETON, S ^{[1
]}

SMITH, J ^{[1
]}

机构：

[1] NYU, MED CTR, NEW YORK, NY 10016 USA

来源：

JOURNAL OF LABORATORY AND CLINICAL MEDICINE | 1976年 / 88卷 / 01期

关键词：

D O I：

暂无

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Endogenous or deliberately added HBsAg was removed and concentrated for assay from albumin and coagulation factor II, VII, IX and X concentrates as model plasma fractions. The concentrates carry considerable risk of causing hepatitis in transfused patients. The amount of antigen remaining in the fraction was estimated at < 1/10,000 of that detectable by the Ausria II radioimmunoassay and 1/100 of that found infectious when highly contaminated human sera were diluted and injected in chimpanzees. Batch fractionation methods with polyethylene glycol were used. The albumin yield was 96%, and the coagulation factors yield about 90%.

引用

页码：91 / 101

页数：11

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