EFFICIENT COUPLING OF ALPHA,ALPHA-DIMETHYL AMINO-ACID USING A NEW CHLORO IMIDAZOLIDIUM REAGENT, CIP

被引：70

作者：

AKAJI, K ^{[1
]}

KURIYAMA, N ^{[1
]}

KISO, Y ^{[1
]}

机构：

[1] KYOTO PHARMACEUT UNIV,DEPT MED CHEM,YAMASHIMA KU,KYOTO 607,JAPAN

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 20期

关键词：

D O I：

10.1016/S0040-4039(00)76895-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

CIP (2-chloro-1,3-dimethylimidazolidium hexafluorophosphate) was an efficient coupling agent for N-alpha-protected alpha-aminoisobutyric acid (Aib) in the presence of an additive. The reactivity was enhanced markedly by a catalytic amount of additive in the order of HOAt similar to HODhbt>DMAP>HOBt. These couplings occurred without detectable racemization.

引用

页码：3315 / 3318

页数：4

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