SYNTHESIS OF ALPHA,ALPHA-DISUBSTITUTED ACETIC-ACIDS USING LOW-VALENT TITANIUM

被引：19

作者：

GARCIA, M ^{[1
]}

DELCAMPO, C ^{[1
]}

LLAMA, EF ^{[1
]}

SINISTERRA, JV ^{[1
]}

机构：

[1] UNIV COMPLUTENSE MADRID, FAC PHARM, DEPT ORGAN & PHARMACEUT CHEM, E-28040 MADRID, SPAIN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 13期

关键词：

D O I：

10.1039/p19950001771

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dihalogenocarbenes generated using low-valent titanium (LVT) undergo a one-pot cycloaddition to diaryl, aryl alkyl or dialkyl ketones to give alpha,alpha-disubstituted acetic acids such as (R,S)-2-arylpropanoic acids. TiI4 proved most effective in this reaction for which the product yield was optimized by use of an excess of reducing agent.

引用

页码：1771 / 1773

页数：3

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