(2R, 4S, 5S)-1-(TETRAHYDRO-4-HYDROXY-5-METHOXY-2-FURANYL)THYMINE - A POTENT SELECTIVE INHIBITOR OF HERPES-SIMPLEX THYMIDINE KINASE

被引：4

作者：

KIM, CU ^{[1
]}

MISCO, PF ^{[1
]}

LUH, BY ^{[1
]}

TERRY, B ^{[1
]}

BISACCHI, G ^{[1
]}

MANSURI, MM ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB PHARMACEUT,RES INST,5 RES PKWY,WALLINGFORD,CT 06492

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)80020-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of thymidine analogues substituted with alkoxy groups on the C-4 position of the furan ring were synthesized. Among these compounds, the methoxy analogue 9 was the most potent inhibitor of herpes simplex virus type 1 thymidine kinase.

引用

页码：1571 / 1576

页数：6

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