IMMUNOSUPPRESSIVE TREATMENT IN MULTIFOCAL MOTOR NEUROPATHY

被引：191

作者：

FELDMAN, EL ^{[1
]}

BROMBERG, MB ^{[1
]}

ALBERS, JW ^{[1
]}

PESTRONK, A ^{[1
]}

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT NEUROL,ST LOUIS,MO 63110

来源：

ANNALS OF NEUROLOGY | 1991年 / 30卷 / 03期

关键词：

D O I：

10.1002/ana.410300312

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report the results of immunosuppressive treatments of 13 patients with multifocal motor neuropathy and elevated titers of serum antibodies to the GM1 ganglioside. All patients failed to respond to oral prednisone. There was no clinical response in 4 patients treated with plasma exchange. Nine patients received cyclophosphamide, with clinical improvement and fall in antibody titers in 8. In 3 patients, cyclophosphamide was discontinued with ensuing clinical relapse and rise in the titers of serum anti-GM1 antibodies. These patients provide further evidence for the efficacy of cyclophosphamide therapy in patients with multifocal motor neuropathy.

引用

页码：397 / 401

页数：5

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