CHROMOSOME-ABERRATIONS IN METASTATIC OVARIAN-CANCER - RELATIONSHIP WITH ABNORMALITIES IN PRIMARY TUMORS

被引：60
|
作者：
BELLO, MJ
REY, JA
机构：
[1] Instituto de Investigaciones Biomédicas Del Csic, Facultad de Medicina de la U.A.M, Madrid, 28029
来源：
INTERNATIONAL JOURNAL OF CANCER | 1990年 / 45卷 / 01期
关键词：
D O I：
10.1002/ijc.2910450111
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Twenty malignant effusions secondary to ovarian cancer have been cytogenetically analyzed directly and after short in vitro culture. With the exception of one sample characterized by trisomy 3, all cases displayed clonal structural rearrangements. Chromosomes 1 and 3 were most frequently involved in the genesis of markers. Abnormalities of chromosomes 5, 6, 9, 11 and 12 were also recurrently found, and double minutes (DM) were observed in 2 samples. Our results agree with previous findings on the preferential involvement of chromosomes 1, 3 and 6 in ovarian carcinomas, and suggest that rearrangements of certain chromosomes are non‐random but are secondary to the malignant progression of these tumors. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
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页码：50 / 54
页数：5
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