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CD44 regulates Wnt signaling at the level of LRP6
被引:14
作者:
Orian-Rousseau, Veronique
[1
,2
]
Schmitt, Mark
[1
,2
]
机构:
[1] Karlsruhe Inst Technol, Karlsruhe, Germany
[2] Inst Toxicol & Genet, Karlsruhe, Germany
关键词:
D O I:
10.4161/23723556.2014.995046
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
CD44 was recently identified as a positive feedback regulator of Wnt/b-catenin signaling. This regulation occurs at the level of low-density lipoprotein receptor-related protein 6 phosphorylation and membrane targeting. These findings broaden our understanding of the Wnt pathway activation process and open new perspectives for anti-CD44 therapies in diseases associated with Wnt induction, including colorectal cancer.
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页数:2
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