CD44 regulates Wnt signaling at the level of LRP6

被引:14
作者
Orian-Rousseau, Veronique [1 ,2 ]
Schmitt, Mark [1 ,2 ]
机构
[1] Karlsruhe Inst Technol, Karlsruhe, Germany
[2] Inst Toxicol & Genet, Karlsruhe, Germany
关键词
D O I
10.4161/23723556.2014.995046
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
CD44 was recently identified as a positive feedback regulator of Wnt/b-catenin signaling. This regulation occurs at the level of low-density lipoprotein receptor-related protein 6 phosphorylation and membrane targeting. These findings broaden our understanding of the Wnt pathway activation process and open new perspectives for anti-CD44 therapies in diseases associated with Wnt induction, including colorectal cancer.
引用
收藏
页数:2
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