CD44 regulates Wnt signaling at the level of LRP6

被引：15

作者：

Orian-Rousseau, Veronique ^{[1
,2
]}

Schmitt, Mark ^{[1
,2
]}

机构：

[1] Karlsruhe Inst Technol, Karlsruhe, Germany

[2] Inst Toxicol & Genet, Karlsruhe, Germany

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2015年 / 2卷 / 03期

关键词：

D O I：

10.4161/23723556.2014.995046

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CD44 was recently identified as a positive feedback regulator of Wnt/b-catenin signaling. This regulation occurs at the level of low-density lipoprotein receptor-related protein 6 phosphorylation and membrane targeting. These findings broaden our understanding of the Wnt pathway activation process and open new perspectives for anti-CD44 therapies in diseases associated with Wnt induction, including colorectal cancer.

引用

页数：2

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