CD44 regulates Wnt signaling at the level of LRP6

被引：14

作者：

Orian-Rousseau, Veronique ^{[1
,2
]}

Schmitt, Mark ^{[1
,2
]}

机构：

[1] Karlsruhe Inst Technol, Karlsruhe, Germany

[2] Inst Toxicol & Genet, Karlsruhe, Germany

来源：

MOLECULAR & CELLULAR ONCOLOGY | 2015年 / 2卷 / 03期

关键词：

D O I：

10.4161/23723556.2014.995046

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CD44 was recently identified as a positive feedback regulator of Wnt/b-catenin signaling. This regulation occurs at the level of low-density lipoprotein receptor-related protein 6 phosphorylation and membrane targeting. These findings broaden our understanding of the Wnt pathway activation process and open new perspectives for anti-CD44 therapies in diseases associated with Wnt induction, including colorectal cancer.

引用

页数：2

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[11] Wnt signaling receptor LRP6 interacts with amyloid precursor protein and regulates its trafficking and processing [J].

Chia-Chen Liu ;

Hyang-Sook Hoe ;

Guojun Bu .

Molecular Neurodegeneration, 7 (Suppl 1)

[12] Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina [J].

Singh, Harminder D. ;

Ma, Jian-xing ;

Takahashi, Yusuke .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2021, 545 :8-13

[13] Merlin inhibits Wnt/β-catenin signaling by blocking LRP6 phosphorylation [J].

M Kim ;

S Kim ;

S-H Lee ;

W Kim ;

M-J Sohn ;

H-S Kim ;

J Kim ;

E-H Jho .

Cell Death & Differentiation, 2016, 23 :1638-1647

[14] Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer [J].

Arensman, Michael D. ;

Nguyen, Phillip ;

Kershaw, Kathleen M. ;

Lay, Anna R. ;

Ostertag-Hill, Claire A. ;

Sherman, Mara H. ;

Downes, Michael ;

Liddle, Christopher ;

Evans, Ronald M. ;

Dawson, David W. .

MOLECULAR CANCER RESEARCH, 2015, 13 (11) :1509-1519

[15] Regulation of Wnt/Lrp6 signalling [J].

Niehrs, Christof .

DIFFERENTIATION, 2010, 80 :S8-S8

[16] Merlin inhibits Wnt/β-catenin signaling by blocking LRP6 phosphorylation [J].

Kim, M. ;

Kim, S. ;

Lee, S-H ;

Kim, W. ;

Sohn, M-J ;

Kim, H-S ;

Kim, J. ;

Jho, E-H .

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[17] Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6 [J].

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Feldman, Michal ;

Kunz, Beatrice ;

Urbe, Sylvie ;

van der Goot, F. Gisou .

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[18] Structure of the Wnt signaling enhancer LYPD6 and its interactions with the Wnt coreceptor LRP6 [J].

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Jones, Edith Yvonne .

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[19] Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation [J].

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Huang, Ya-Lin ;

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Zimmermann, Timo ;

Cruciat, Cristina-Maria ;

Bienz, Mariann ;

Niehrs, Christof .

SCIENCE, 2007, 316 (5831) :1619-1622

[20] WNT-induced association of Frizzled and LRP6 is not sufficient for the initiation of WNT/β-catenin signaling [J].

Voss, Jan Hendrik ;

Koszegi, Zsombor ;

Yan, Yining ;

Shorter, Emily ;

Gratz, Lukas ;

Lanner, Johanna T. ;

Calebiro, Davide ;

Schulte, Gunnar .

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