CD44 regulates Wnt signaling at the level of LRP6

被引：14
|
作者：
Orian-Rousseau, Veronique [1 ,2 ]
Schmitt, Mark [1 ,2 ]
机构：
[1] Karlsruhe Inst Technol, Karlsruhe, Germany
[2] Inst Toxicol & Genet, Karlsruhe, Germany
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2015年 / 2卷 / 03期
关键词：
D O I：
10.4161/23723556.2014.995046
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
CD44 was recently identified as a positive feedback regulator of Wnt/b-catenin signaling. This regulation occurs at the level of low-density lipoprotein receptor-related protein 6 phosphorylation and membrane targeting. These findings broaden our understanding of the Wnt pathway activation process and open new perspectives for anti-CD44 therapies in diseases associated with Wnt induction, including colorectal cancer.
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页数：2
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