CpG Islands Occurrences in DNA Sequences

被引：0

作者：

Figueira, Cleonis V. ^{[1
]}

Lopes, Silvia Regina C. ^{[2
]}

机构：

[1] UTFPR PR, Dept Matemat, Curitiba, Parana, Brazil

[2] UFRGS RS, Dept Matemat, Porto Alegre, RS, Brazil

来源：

SIGMAE | 2013年 / 2卷 / 03期

关键词：

DNA Sequences; CpG Islands; Methylation; CpG Incidence Rate;

D O I：

暂无

中图分类号：

O1 [数学];

学科分类号：

0701 ; 070101 ;

摘要：

This paper presents a comparison among three chromosomes from different organisms: Saccharomyces cerevisiae chromosome 12, Homo sapiens chromosome 22 and Drosophila melanogaster chromosome 3L. The aim is to analyze the incidence of dinucleotides CpG at intervals of DNA sequence of each chromosome, seeking for the existence of CpG islands (ICpG). According to the literature, D. melanogaster and S. cerevisiae show no methylation or bring strong suppression of methylation, a modification of the cytosine dinucleotide ICpG occurring significantly in the ICpG. The existence of these islands methylation are important for research in the context of mutations and pathologies related to different types of diseases. Some Monte Carlo simulations for the occurrence of methylation in ICpG are also presented..

引用

页码：100 / 106

页数：7

共 6 条

[1] NUMBER OF CPG ISLANDS AND GENES IN HUMAN AND MOUSE
ANTEQUERA, F
BIRD, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) : 11995 - 11999
[2] Bird A, 1995, J CELL SCI, P37
[3] CPG ISLANDS IN VERTEBRATE GENOMES
GARDINERGARDEN, M
FROMMER, M
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1987, 196 (02) : 261 - 282
[4] MODEL F., 2009, STAT INFORM MOL CANC
[5] R Core Team, 2022, R LANG ENV STAT COMP
[6] Redefining CpG islands using hidden Markov models
Wu, Hao
Caffo, Brian
Jaffee, Harris A.
Irizarry, Rafael A.
Feinberg, Andrew P.
[J]. BIOSTATISTICS, 2010, 11 (03) : 499 - 514

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