MPTP, THE NEUROTOXIN INDUCING PARKINSONS-DISEASE, IS A POTENT COMPETITIVE INHIBITOR OF HUMAN AND RAT CYTOCHROME-P450 ISOZYMES (P450BUFI, P450DB1) CATALYZING DEBRISOQUINE 4-HYDROXYLATION

被引：148
作者：
FONNEPFISTER, R
BARGETZI, MJ
MEYER, UA
机构：
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1987年 / 148卷 / 03期
关键词：
D O I：
10.1016/S0006-291X(87)80252-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：1144 / 1150
页数：7
相关论文
共 28 条
[1]  
BARBEAU A, 1985, LANCET, V2, P1213
[2]   SIMPLE GRAPHICAL METHOD FOR DETERMINING INHIBITION CONSTANTS OF MIXED, UNCOMPETITIVE AND NON-COMPETITIVE INHIBITORS [J].
CORNISHB.A .
BIOCHEMICAL JOURNAL, 1974, 137 (01) :143-144
[3]   CHRONIC PARKINSONISM SECONDARY TO INTRAVENOUS-INJECTION OF MEPERIDINE ANALOGS [J].
DAVIS, GC ;
WILLIAMS, AC ;
MARKEY, SP ;
EBERT, MH ;
CAINE, ED ;
REICHERT, CM ;
KOPIN, IJ .
PSYCHIATRY RESEARCH, 1979, 1 (03) :249-254
[4]   CHARACTERIZATION OF A COMMON GENETIC-DEFECT OF CYTOCHROME-P-450 FUNCTION (DEBRISOQUINE-SPARTEINE TYPE POLYMORPHISM) - INCREASED MICHAELIS CONSTANT (KM) AND LOSS OF STEREOSELECTIVITY OF BUFURALOL 1'-HYDROXYLATION IN POOR METABOLIZERS [J].
DAYER, P ;
GASSER, R ;
GUT, J ;
KRONBACH, T ;
ROBERTZ, GM ;
EICHELBAUM, M ;
MEYER, UA .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 125 (01) :374-380
[5]   THE GENETIC-CONTROL OF BUFURALOL METABOLISM IN MAN [J].
DAYER, P ;
BALANT, L ;
COURVOISIER, F ;
KUPFER, A ;
KUBLI, A ;
GORGIA, A ;
FABRE, J .
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 1982, 7 (01) :73-77
[6]   THE DETERMINATION OF ENZYME INHIBITOR CONSTANTS [J].
DIXON, M .
BIOCHEMICAL JOURNAL, 1953, 55 (01) :170-171
[7]   DEFECTIVE N-OXIDATION OF SPARTEINE IN MAN - NEW PHARMACOGENETIC DEFECT [J].
EICHELBAUM, M ;
SPANNBRUCKER, N ;
STEINCKE, B ;
DENGLER, HJ .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1979, 16 (03) :183-187
[8]  
EICHELBAUM M, 1982, CLIN PHARMACOKINET, V7, P1, DOI 10.2165/00003088-198207010-00001
[9]   REGIONAL STUDIES OF CATECHOLAMINES IN RAT BRAIN .I. DISPOSITION OF [3H]NOREPINEPHRINE [3H]DOPAMINE AND [3H]DOPA IN VARIOUS REGIONS OF BRAIN [J].
GLOWINSKI, J ;
IVERSEN, LL .
JOURNAL OF NEUROCHEMISTRY, 1966, 13 (08) :655-+
[10]   DEBRISOQUINE 4-HYDROXYLASE - CHARACTERIZATION OF A NEW P450 GENE SUBFAMILY, REGULATION, CHROMOSOMAL MAPPING, AND MOLECULAR ANALYSIS OF THE DA RAT POLYMORPHISM [J].
GONZALEZ, FJ ;
MATSUNAGA, T ;
NAGATA, K ;
MEYER, UA ;
NEBERT, DW ;
PASTEWKA, J ;
KOZAK, CA ;
GILLETTE, J ;
GELBOIN, HV ;
HARDWICK, JP .
DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY, 1987, 6 (02) :149-161
123