PLATELET HETEROGENEITY BASED ON LACTIC-DEHYDROGENASE ACTIVITY

被引：3

作者：

DESOLE, P ^{[1
]}

ZAPPACOSTA, B ^{[1
]}

机构：

[1] UNIV CATTOLICA SACRO CUORE, 1ST FISIOL UMANA, SERV CHIM CLIN, I-00168 ROME, ITALY

来源：

ANNALS OF HEMATOLOGY | 1992年 / 65卷 / 03期

关键词：

PLATELET; LACTIC DEHYDROGENASE;

D O I：

10.1007/BF01695813

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mean lactic dehydrogenase (LDH) activity of human platelets is about 5 nU/platelet; expressed on a cell volume basis, it is 0.5 nU/fl. Platelet separation by means of centrifugation on a Percoll discontinuous gradient gives different subpopulations with a clear-cut change of LDH at a mean platelet volume (MPV) of about 6 fl. The LDH content of platelets with a MPV > 6 fl is constant (about 0.5 nU/fl), while that of small platelets (3 < MPV < 6 fl) is inversely correlated with the MPV and reaches a value of 1.5-2.0 nU/fl. Because small platelets are granule-depleted, we suggest that platelet LDH activity be considered as an in vivo activation index.

引用

页码：135 / 137

页数：3

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