PARKINSONISM-INDUCING NEUROTOXIN MPP+ - UPTAKE AND TOXICITY IN NONNEURONAL COS CELLS EXPRESSING DOPAMINE TRANSPORTER CDNA

被引：83

作者：

KITAYAMA, S

SHIMADA, S

UHL, GR

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROSCI,BALTIMORE,MD 21205

来源：

ANNALS OF NEUROLOGY | 1992年 / 32卷 / 01期

关键词：

D O I：

10.1002/ana.410320120

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Expression of a cloned dopamine transporter complementary DNA in COS cells allows these primate kidney cells to accumulate the parkinsonism-inducing neurotoxin metabolite MPP+ (1-methyl-4-phenylpyridinium) avidly, and MPP+ toxicity results. By documenting that the dopamine transporter can confer MPP+ sensitivity to nonneural cells, these results highlight the key role that this transporter could play in mechanisms underlying parkinsonism.

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页码：109 / 111

页数：3

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