ONE-DIMENSIONAL AND TWO-DIMENSIONAL H-1-NMR STUDY OF THE SUBSTANCE-P FRAGMENT ARG-PRO-LYS-PRO

被引：10

作者：

OTTER, A

KOTOVYCH, G

STEWART, JM

机构：

[1] UNIV ALBERTA, DEPT CHEM, EDMONTON T6G 2G2, ALBERTA, CANADA

[2] UNIV COLORADO, DEPT BIOCHEM, DENVER, CO 80262 USA

来源：

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS | 1986年 / 3卷 / 06期

关键词：

D O I：

10.1080/07391102.1986.10508489

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Substance P fragment Arg1-Pro2-Lys3-Pro4 (SP1-4) has been extensively investigated by means of proton nuclear magnetic resonance at 400 MHz. The combined application of different 2D techniques and a comparison of SP1-4 with its derivative SP1-4-amide allowed the complete and unambiguous assignment of the proton NMR spectrum. Conformational data obtained from the different NMR parameters are compared with theoretical calculations. The results suggest that SP1-4 exists, at the chosen experimental conditions, as a stretched molecule.

引用

页码：1121 / 1131

页数：11

共 21 条

[1]

[Anonymous], 1970, Biochemistry, V9, P3471

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