PROTECTING GROUP IMPROVEMENT BY ISOTOPIC-SUBSTITUTION - APPLICATION TO THE SYNTHESIS OF THE QUINONE SYSTEM OF FREDERICAMYCIN-A

被引：12

作者：

CLIVE, DLJ

KHODABOCUS, A

CANTIN, M

TAO, Y

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 24期

关键词：

D O I：

10.1039/c39910001755

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Use of a trideuteriomethoxy group for phenol protection, instead of the classical methoxy group, serves to suppress an unwanted intramolecular hydrogen transfer during a radical cyclization experiment, and leads to a spiro compound of a type that can be converted into the spiro diketone-quinone system of the antitumour agent, fredericamycin A.

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页码：1755 / 1757

页数：3

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