INVOLVEMENT OF THE CHOLINERGIC NEURONAL SYSTEM AND BENZODIAZEPINE RECEPTORS IN ALCOHOL-INDUCED AMNESIA

被引：0
|
作者：
NABESHIMA, T [1 ]
TOHYAMA, K [1 ]
ISHIHARA, S [1 ]
KAMEYAMA, T [1 ]
机构：
[1] NAGOYA UNIV,SCH MED,DEPT HOSP PHARM,NAGOYA,AICHI 466,JAPAN
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 195卷 / 02期
关键词：
ETHANOL; CHLORDIAZEPOXIDE; BICUCULLINE; GABA-A-RECEPTORS; PHYSOSTIGMINE; CHOLINERGIC NEURONAL SYSTEM;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We investigated the involvement of the GABAergic and cholinergic neuronal systems and benzodiazepine (BZP) receptors in ethanol-induced amnesia using a passive avoidance task. Pretraining administration of ethanol impaired the passive avoidance response. The BZP agonist chlordiazepoxide potentiated the amnesia, while the GABA antagonists bicuculline and picrotoxin failed to affect it. The acetylcholine esterase inhibitor physostigmine partially attenuated the ethanol-induced amnesia. These results suggest that ethanol-induced amnesia is related to BZP receptors and a dysfunction of the cholinergic neuronal system.
引用
收藏
页码：285 / 289
页数：5
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