INHIBITION OF ACYL COA - CHOLESTEROL ACYLTRANSFERASE AND STEROLOGENESIS IN RAT-LIVER BY DIAZEPAM, INVITRO

被引：8
作者：
BELL, FP
机构：
来源：
LIPIDS | 1985年 / 20卷 / 02期
关键词：
D O I：
10.1007/BF02534211
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diazepam, a commonly prescribed tranquilizer, was found to inhibit cholesterol biosynthesis in rat liver minces; inhibition appeared to occur at multiple postmevalonate sites. Diazepam also inhibited cholesterol esterification by acylCoA:cholesterol acyltransferase in isolated liver microsomes and minces. Liver minces incubated with [14C]oleate demonstrated increased uptake of the fatty acid and a greater incorporation of the substrates into triglycerides, diglycerides and phospholipids when diazepam was present. The results suggest possible mechanisms for the hypocholesterolemic effect of diazepam in experimental animals and for the elevation of triglycerides and very low-density lipoproteins in man and the rat. [The possible use of diazepam in treating atherosclerosis is discussed.].
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页码：75 / 79
页数：5
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共 33 条
[1]   THE EFFECT OF LIDOCAINE ON CHOLESTEROL INFLUX, ESTERIFICATION, AND ACCUMULATION IN CULTURED-CELLS [J].
BELL, FP ;
ROTHBLAT, GH ;
BAMBERGER, M .
CANADIAN JOURNAL OF BIOCHEMISTRY, 1982, 60 (10) :967-971
[2]   MEMBRANE-ACTIVE AGENTS - EFFECT OF VARIOUS ANESTHETICS AND CHLORPROMAZINE ON ARTERIAL LIPID-METABOLISM [J].
BELL, FP ;
HUBERT, EV .
ATHEROSCLEROSIS, 1981, 39 (04) :517-525
[3]  
BELL FP, 1980, BIOCHIM BIOPHYS ACTA, V619, P302, DOI 10.1016/0005-2760(80)90078-8
[4]   THE EFFECT OF LOCAL-ANESTHETICS ON ARTERIAL LIPID-METABOLISM - INHIBITION OF STEROL ESTERIFICATION INVITRO [J].
BELL, FP .
ATHEROSCLEROSIS, 1981, 38 (1-2) :81-88
[5]   EFFECT OF PHTHALATE ESTERS ON SERUM-CHOLESTEROL AND LIPID BIOSYNTHESIS IN LIVER, TESTES, AND EPIDIDYMAL FAT IN RAT AND RABBIT [J].
BELL, FP ;
PATT, CS ;
GILLIES, PJ .
LIPIDS, 1978, 13 (10) :673-678
[6]   EFFECT OF CHLORPROMAZINE ON LIPID-METABOLISM IN AORTAS FROM CHOLESTEROL-FED RABBITS AND NORMAL RATS, INVITRO - INHIBITION OF STEROL ESTERIFICATION AND MODIFICATION OF PHOSPHOLIPID-SYNTHESIS [J].
BELL, FP .
EXPERIMENTAL AND MOLECULAR PATHOLOGY, 1983, 38 (03) :336-345
[7]   BIOSYNTHESIS OF VARIOUS STEROLS, STEROL ESTERS, AND SQUALENE FROM [MEVALONATE-C-14] BY NORMAL SWINE INTIMA AND MEDIA INVITRO - COMPARATIVE-STUDY [J].
BELL, FP .
EXPERIMENTAL AND MOLECULAR PATHOLOGY, 1976, 25 (03) :279-292
[8]   EVIDENCE THAT CHLORPROMAZINE INHIBITS STEROLOGENESIS AT POST-HMGCOA REDUCTASE SITES IN RAT-LIVER, INVITRO [J].
BELL, FP ;
HUBERT, EV .
LIPIDS, 1983, 18 (09) :668-671
[9]   INHIBITION OF HEPATIC STEROL AND SQUALENE BIOSYNTHESIS IN RATS FED DI-2-ETHYLHEXYL PHTHALATE [J].
BELL, FP .
LIPIDS, 1976, 11 (10) :769-773
[10]   DIAZEPAM INHIBITS CHOLESTEROL ESTERIFICATION BY ARTERIAL ACAT AND PLASMA LCAT, INVITRO [J].
BELL, FP .
ATHEROSCLEROSIS, 1984, 50 (03) :345-352
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