Amyotrophic lateral sclerosis: one or multiple causes?

被引：24

作者：

Bastos, Aline Furtado ^{[1
]}

Orsini, Marco ^{[2
,3
]}

Machado, Dionis ^{[4
]}

Mello, Mariana Pimentel ^{[1
]}

Nader, Sergio ^{[5
]}

Silva, Julio Guilherme ^{[2
,6
]}

da Silva Catharino, Antonio M. ^{[7
]}

de Freitas, Marcos R. G. ^{[2
]}

Pereira, Alessandra ^{[8
]}

Pessoa, Luciane Lacerda ^{[8
]}

Sztajnbok, Flavio R. ^{[8
]}

Leite, Marco Araujo ^{[2
]}

Nascimento, Osvaldo J. M. ^{[2
]}

Bastos, Victor Hugo ^{[9
]}

机构：

[1] Serra Dos Orgaos Univ, Rio De Janeiro, Brazil

[2] Univ Fed Fluminense, Rio De Janeiro, Brazil

[3] Grande Rio Univ, Dept Med, Rio De Janeiro, Brazil

[4] Fed Univ Jequitinhonha & Mucuri Valleys, Diamantina, MS, Brazil

[5] Rio De Janeiro Fed Univ, Rio De Janeiro, Brazil

[6] Cent Univ Augusto Motta, Masters Program Rehabil, Rio De Janeiro, Brazil

[7] Nova Iguacu Univ, Rio De Janeiro, Brazil

[8] Grande Rio Univ, Dept Med, Rio Grande, Brazil

[9] Fed Univ Jequitinhonha & Mucuri, Diamantina, Minas Gerais, Brazil

来源：

NEUROLOGY INTERNATIONAL | 2011年 / 3卷 / 01期

关键词：

motor neuron disease; neuromuscular Diseases; amyotrophic lateral sclerosis; etiology; hypothesis; review;

D O I：

10.4081/ni.2011.e4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease in the adulthood, and it is characterized by rapid and progressive compromise of the upper and lower motor neurons. The majority of the cases of ALS are classified as sporadic and, until now, a specific cause for these cases still is unknown. To present the different hypotheses on the etiology of ALS. It was carried out a search in the databases: Bireme, Scielo and Pubmed, in the period of 1987 to 2011, using the following keywords: Amyotrophic lateral sclerosis, motor neuron disease, etiology, causes and epidemiology and its similar in Portuguese and Spanish. It did not have consensus as regards the etiology of ALS. Researches demonstrates evidences as regards intoxication by heavy metals, environmental and occupational causes, genetic mutations (superoxide dismutase 1), certain viral infections and the accomplishment of vigorous physical activity for the development of the disease. There is still no consensus regarding the involved factors in the etiology of ALS. In this way, new research about these etiologies are necessary, for a better approach of the patients, promoting preventive programs for the disease and improving the quality of life of the patients.

引用

页码：12 / 16

页数：5

共 58 条

[1]

Akhvlediani T, 2009, Georgian Med News, P70

[2] An evidence-based medicine approach to the evaluation of the role of exogenous risk factors in sporadic amyotrophic lateral sclerosis [J].