Diabetes and tuberculosis: A review of the role of optimal glycemic control

被引：72

作者：

Asfandyar Khan Niazi

Sanjay Kalra

机构：

[1] Shifa College of Medicine

[2] Bharti Hospital and B.R.I.D.E, Karnal

来源：

Journal of Diabetes & Metabolic Disorders | / 11卷 / 1期

关键词：

Anti-tubercular treatment; Epidemic; Glycemic control; Insulin; Oral hypoglycemic drugs;

D O I：

10.1186/2251-6581-11-28

中图分类号：

学科分类号：

摘要：

Developing countries shoulder most of the burden of diabetes and tuberculosis. These diseases often coexist. Suboptimal control of diabetes predisposes the patient to tuberculosis, and is one of the common causes of poor response to anti-tubercular treatment. Tuberculosis also affects diabetes by causing hyperglycemia and causing impaired glucose tolerance. Impaired glucose tolerance is one of the major risk factors for developing diabetes. The drugs used to treat tuberculosis (especially rifampicin and isoniazid) interact with oral anti-diabetic drugs and may lead to suboptimal glycemic control. Similarly some of the newer oral anti-diabetic drugs may interact with anti-tuberculosis drugs and lower their efficacy. Therefore diabetes and tuberculosis interact with each other at multiple levels - each exacerbating the other. Management of patients with concomitant tuberculosis and diabetes differs from that of either disease alone. This article reviews the association between diabetes and tuberculosis and suggests appropriate management for these conditions. © 2012 Niazi and Kalra; licensee BioMed Central Ltd.

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