IMMUNOSTIMULATORY ACTIVITY OF PICRORHIZA-KURROA LEAF EXTRACT

被引：43
作者：
SHARMA, ML
RAO, CS
DUDA, PL
机构：
[1] UNIV JAMMU, DEPT BIOSCI, JAMMU, JAMMU & KASHMIR, INDIA
[2] BITS, PILANI, RAJASTHAN, INDIA
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 1994年 / 41卷 / 03期
关键词：
PICRORHIZA KURROA; SCROPHULARIACEAE; IMMUNOSTIMULATORY; CELL MEDIATED IMMUNITY; HUMORAL IMMUNITY; PHAGOCYTOSIS;
D O I：
10.1016/0378-8741(94)90031-0
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A 50% ethanolic extract of Picrorhiza kurroa Royle ex Benth. (Scrophulariaceae) leaves (PKLE) was found to stimulate the cell-mediated and humoral components of the immune system as well as phagocytosis in experimental animals. PKLE elicited a dose-related increase in SRBC, induced 4 h (early) and 24 h (delayed) hypersensitivity reactions in mice and rats, and horse serum induced Arthus reaction in guinea pigs. It also enhanced the humoral immune responses in mice and rats and phagocytic function of the cells of the reticuloendothelial system in mice. PKLE exhibited no mitogenic activity but augmented the responsiveness of murine splenocytes to T cell mitogens phytohaemagglutinin (PHA) and concanavalin A (Con A) and B cell mitogen lipopolysaccharide (LPS E. coli).
引用
收藏
页码：185 / 192
页数：8
相关论文
共 45 条
  • [1] ANSARI RA, 1988, INDIAN J MED RES, V87, P401
  • [2] ANTARKAR DS, 1980, INDIAN J MED RES, V72, P588
  • [3] IMMUNOMODULATING AGENTS OF PLANT-ORIGIN .1. PRELIMINARY SCREENING
    ATAL, CK
    SHARMA, ML
    KAUL, A
    KHAJURIA, A
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 1986, 18 (02) : 133 - 141
  • [4] PICRORHIZA-KURROA, AN AYURVEDIC HERB, MAY POTENTIATE PHOTOCHEMOTHERAPY IN VITILIGO
    BEDI, KL
    ZUTSHI, U
    CHOPRA, CL
    AMLA, V
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 1989, 27 (03) : 347 - 352
  • [5] BENACERRAF B, 1978, J IMMUNOL, V120, P1809
  • [6] BLOKSMA N, 1980, ANN INST PASTEUR IMM, VD131, P255
  • [7] CHARAK, 1935, CHARAK SAMHITA, P159
  • [8] CHATURVEDI GN, 1966, J RES IND MED, V1, P1
  • [9] Chopra R. N., 1958, CHOPRAS INDIGENOUS D, P181
  • [10] COCHRANE CG, 1974, INFLAMMATORY PROCESS, V3, P85
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