A 3-WEEK HEPATITIS-B VACCINATION SCHEDULE PROVIDES RAPID AND PERSISTENT PROTECTIVE IMMUNITY - A MULTICENTER, RANDOMIZED TRIAL COMPARING ACCELERATED AND CLASSIC VACCINATION SCHEDULES

被引：38
作者：
MARCHOU, B
EXCLER, JL
BOURDERIOUX, C
SALAUN, J
PICOT, N
YVONNET, B
CERISIER, JE
SALOMON, H
AUVERGNAT, JC
机构：
[1] HOP BRETONNEAU,SERV MALAD INFECT & TROP,PARIS,FRANCE
[2] FAC PHARM TOURS,INST VIROL,TOURS,FRANCE
[3] FAC PHARM TOURS,MICROBIOL LAB,TOURS,FRANCE
[4] CASERNE LOURCINES,PARIS,FRANCE
[5] PASTEUR MERIEUX SERUMS & VACCINS,MARNES COQUETTE,FRANCE
来源：
JOURNAL OF INFECTIOUS DISEASES | 1995年 / 172卷 / 01期
关键词：
D O I：
10.1093/infdis/172.1.258
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Hepatitis B (HB) vaccinations given once weekly for 3 weeks can provide early seroprotection. This study compared immune responses induced by the accelerated (A; days 0, 10, 21) and classic (C; days 0, 28, 56) HB vaccination schedules. Two hundred seventy healthy subjects (95 men, 175 women) with a mean age of 23.8 years received 3 doses of GenHevac B, a recombinant vaccine produced in mammalian cells. The subjects were randomly assigned to schedules A or C. A booster dose was given 1 year later. One month after the third dose, 70% (schedule A) and 92% (schedule C) of the subjects were seroprotected and 100% (A) and 99% (C) of the subjects were seroprotected, and 1 month after the booster, almost all subjects were seroprotected. A 3-week HB vaccination schedule with GenHevac B can confer early protective immunity lasting up to 1 year.
引用
收藏
页码：258 / 260
页数：3
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