SATTABACINS AND SATTAZOLINS - NEW BIOLOGICALLY-ACTIVE COMPOUNDS WITH ANTIVIRAL PROPERTIES EXTRACTED FROM A BACILLUS SP

被引：40

作者：

LAMPIS, G

DEIDDA, D

MAULLU, C

MADEDDU, MA

POMPEI, R

MONACHE, FD

SATTA, G

机构：

[1] UNIV CATTOLICA ROMA,IST CHIM,CNR,CTR STUDI CHIM RECETTORI & MOLEC BIOL ATT,I-00168 ROME,ITALY

[2] UNIV CATTOLICA ROMA,IST MICROBIOL,I-00168 ROME,ITALY

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 09期

关键词：

D O I：

10.7164/antibiotics.48.967

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A series of new compounds with antiviral properties were isolated from a Bacillus sp. strain B-60. They were named sattabacin (1), hydroxysattabacin (2), sattazolin (3) and methylsattazolin (4). The biologically active compounds were recovered from fermentation broth by ethyl acetate extraction and silica-gel column fractionation. Their antiviral activity was mainly expressed against the Herpes simplex viruses type 1 and 2. The compound 3 showed a selective inhibition of protein synthesis in Herpesvirus-infected cells.

引用

页码：967 / 972

页数：6

共 13 条

[1]

AMSTERDAM D, 1991, ANTIBIOTICS LAB MED, P53

[2]

COOPER BH, 1985, MANUAL CLIN MICROBIO, P526

[3] C-13 NUCLEAR MAGNETIC-RESONANCE SPECTRA OF ALKYL INDOLES INCLUDING DERIVATIVES OF HEXAHYDROECHINULIN [J].